FOXO1 belongs to the winged helix/forkhead family of transcription factors that is characterized by a 100-amino acid monomeric DNA-binding domain called the FOX domain. In vitro and in vivo studies have shown that FOXO transcription factors control the regulation of many genes involved in fundamental cellular processes, including cell cycle regulation, cell death, modulation of inflammation, metabolism, protection from oxidative stress, and cell survival. FOXO1 is broadly expressed in different types of cells with high level of expression in lymphoid cells and non-Hodgkin's lymphomas. In contrast, in most of classical Hodgkin lymphoma (cHL), Reed-Sternberg cells were FOXO1 negative.
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FOXO1 (EP290)
Rabbit Monoclonal
FOXO1 belongs to the winged helix/forkhead family of transcription factors that is characterized by a 100-amino acid monomeric DNA-binding domain called the FOX domain. In vitro and in vivo studies have shown that FOXO transcription factors control the regulation of many genes involved in fundamental cellular processes, including cell cycle regulation, cell death, modulation of inflammation, metabolism, protection from oxidative stress, and cell survival. FOXO1 is broadly expressed in different types of cells with high level of expression in lymphoid cells and non-Hodgkin's lymphomas. In contrast, in most of classical Hodgkin lymphoma (cHL), Reed-Sternberg cells were FOXO1 negative.
Rabbit Monoclonal
FOXO1 belongs to the winged helix/forkhead family of transcription factors that is characterized by a 100-amino acid monomeric DNA-binding domain called the FOX domain. In vitro and in vivo studies have shown that FOXO transcription factors control the regulation of many genes involved in fundamental cellular processes, including cell cycle regulation, cell death, modulation of inflammation, metabolism, protection from oxidative stress, and cell survival. FOXO1 is broadly expressed in different types of cells with high level of expression in lymphoid cells and non-Hodgkin's lymphomas. In contrast, in most of classical Hodgkin lymphoma (cHL), Reed-Sternberg cells were FOXO1 negative.
