E2F4 is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. This protein binds to all three of the tumor suppressor proteins pRB, p107 and p130, but with higher affinity to the last two. In quiescent cells, E2F4 is primarily localized in the nucleus but translocate to cytoplasm when the retinoblastoma family members are phosphorylated in response to mitogen. E2F4 is constitutively expressed throughout the cell. Squamous cell carcinomas of the salivary gland show a high E2F4 cytoplasmic staining score, while most of the pleomorphic adenoma cells show nuclear reactivity of E2F4. Reduced expression of E2F4 has been reported in sporadic Burkitt lymphoma (sBL). E2F4 may play a role in Burkitt lymphoma tumorigenesis.
Literature:
Manufacturer site:
E2F4 (EP252)
Rabbit Monoclonal
E2F4 is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. This protein binds to all three of the tumor suppressor proteins pRB, p107 and p130, but with higher affinity to the last two. In quiescent cells, E2F4 is primarily localized in the nucleus but translocate to cytoplasm when the retinoblastoma family members are phosphorylated in response to mitogen. E2F4 is constitutively expressed throughout the cell. Squamous cell carcinomas of the salivary gland show a high E2F4 cytoplasmic staining score, while most of the pleomorphic adenoma cells show nuclear reactivity of E2F4. Reduced expression of E2F4 has been reported in sporadic Burkitt lymphoma (sBL). E2F4 may play a role in Burkitt lymphoma tumorigenesis.
Rabbit Monoclonal
E2F4 is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. This protein binds to all three of the tumor suppressor proteins pRB, p107 and p130, but with higher affinity to the last two. In quiescent cells, E2F4 is primarily localized in the nucleus but translocate to cytoplasm when the retinoblastoma family members are phosphorylated in response to mitogen. E2F4 is constitutively expressed throughout the cell. Squamous cell carcinomas of the salivary gland show a high E2F4 cytoplasmic staining score, while most of the pleomorphic adenoma cells show nuclear reactivity of E2F4. Reduced expression of E2F4 has been reported in sporadic Burkitt lymphoma (sBL). E2F4 may play a role in Burkitt lymphoma tumorigenesis.
