Cytokeratin 5 (CK5) is a type II cytokeratin. CK5 labels myoepithelial cells of breast and prostate basal cells. Eighty percent of prostate tumors contain genomic fusions of TMPRSS2 and members of the ETS family of transcription factors. Of these, about 50% contain TMPRSS2-ERG fusions. Interestingly, prostate cancers with TMPRSS2-ERG fusion have been found to have five morphological features: blue-tinged mucin, cribriform growth pattern, macronucleoli, intraductal tumor spread, and signet-ring cell features. ERG overexpression is associated with aggressive tumor behavior and patient survival in prostate cancer. The ERG antibody labels prostate cancer cells, endothelial cells, and lymphocytes.
Cytokeratin 5 (CK5) is a type II cytokeratin. CK5 labels myoepithelial cells of breast and prostate basal cells. Eighty percent of prostate tumors contain genomic fusions of TMPRSS2 and members of the ETS family of transcription factors. Of these, about 50% contain TMPRSS2-ERG fusions. Interestingly, prostate cancers with TMPRSS2-ERG fusion have been found to have five morphological features: blue-tinged mucin, cribriform growth pattern, macronucleoli, intraductal tumor spread, and signet-ring cell features. ERG overexpression is associated with aggressive tumor behavior and patient survival in prostate cancer. The ERG antibody labels prostate cancer cells, endothelial cells, and lymphocytes.
Cytokeratin 5 (CK5) is a type II cytokeratin. CK5 labels myoepithelial cells of breast and prostate basal cells. Eighty percent of prostate tumors contain genomic fusions of TMPRSS2 and members of the ETS family of transcription factors. Of these, about 50% contain TMPRSS2-ERG fusions. Interestingly, prostate cancers with TMPRSS2-ERG fusion have been found to have five morphological features: blue-tinged mucin, cribriform growth pattern, macronucleoli, intraductal tumor spread, and signet-ring cell features. ERG overexpression is associated with aggressive tumor behavior and patient survival in prostate cancer. The ERG antibody labels prostate cancer cells, endothelial cells, and lymphocytes.
